A fatal house fire has claimed a second victim after a badly burned man succumbed to his injuries in hospital.

The 84-year-old , and a 44 year old man, had escaped the engulfed two-storey Gold Coast home via the garage after they tried to rescue a fellow resident on Wednesday.

The two men were critically injured when they tried to break into a locked bedroom and save the person inside but were forced to retreat from the flames.

The body of a 38 year old man – who is yet to be formally identified – was found in the bedroom after firefighting crews took almost two hours to extinguish the fire at the Hope Island home.

The 84-year-old and 44-year-old were rushed to hospital with burns to their heads, necks, chests, backs, arms and legs.

Queensland Police confirmed on Thursday morning that the older man – who had burns to 50 cent of his body – had died in a Brisbane hospital on Wednesday.

They said the 44-year-old – who had burns to 40 per cent of his body – remained in a critical condition.

Two other people – a 59-year-old woman and a 38-year-old man – escaped the blaze by jumping off an upper level balcony. The woman remains in hospital after suffering a back injury.

The badly damaged house was declared a crime scene, but the cause of the fire was still unknown, police said on Wednesday.

Detective Superintendent Chris Ahearn said the house’s occupants were known to police after a disturbance was reported last week,

Two occupants were the subject of domestic violence orders that did not prevent them from living in the same residence, he said.

1800 RESPECT 1800 737 732

Lifeline 131 114

Men’s Referral Service 1300 766 491

Lifeline 131 114

beyondblue 1300 224 636

-AAP