Notorious gang rapist Mohammed Skaf has been hit with a string of fresh charges, including large-scale drug supply offences and directing a criminal group.

Skaf was released from prison in 2021 after serving 21 years behind bars for his role in a series of horrific pack rapes.

The 42-year-old was re-arrested in the south-west Sydney suburb of Greenacre on Wednesday after a police investigation into alleged drug supply activity.

During his arrest and a subsequent search, police allegedly found nearly $250,000 in cash, as well as cocaine, MDMA and several mobile phones.

A short time later, a 51-year-old man was also arrested at a unit in Bankstown and a 54-year-old woman was arrested at a unit in Newington.

Skaf was charged with 24 offences, including supplying a commercial quantity of drugs and knowingly directing the activities of a criminal group.

During a search of the unit where the older man was arrested, police allegedly found a ballistic vest, a baton and steroids. An amount of ketamine and MDMA were allegedly found in the unit where the woman was arrested.

The woman and the older man were charged with offences including supplying prohibited drugs and participating in a criminal group.

All three were refused bail and the two men were due to face Bankstown Local Court on Thursday.

Mohammed Skaf was arrested by NSW Police in Greenacre. Photo: NSW Police

As a 17-year-old, Skaf was part of a group of more than a dozen teenagers and young men who were responsible for six gang rapes.

His brother Bilal was the ringleader in the 2000 crimes, which involved victims being lured with the promise of smoking marijuana before they were repeatedly sexually assaulted.

Skaf was refused parole several times before being released in 2021.

A parole hearing shortly before he was let out of custody heard he continued to blame his victims.

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National Sexual Abuse and Redress Support Service 1800 211 028

-AAP