Two children have died and five other children were injured in a horror rollover on the way home from school in Victoria.

It’s understood a woman, aged 34, was driving and there were seven children in the eight-seater 4WD in what may have been a carpooling arrangement.

The vehicle reportedly ran off the road at Parwan, about one hour west of Melbourne, on Tuesday afternoon and rolled several times.

There were chaotic and distressing scenes as families rushed to the accident site and witnesses stopped to help.

One child, aged seven, died at the scene despite receiving CPR and a second child, aged 11, died later in hospital after being airlifted.

Five other children had minor injuries and the female driver was under observation in hospital.

Emergency services were called to the site of the single-vehicle crash shortly before 4pm on Tuesday.

Investigations into the circumstances surrounding the crash are ongoing.

Channel Seven’s Sunrise reports that potholes were not believed to have contributed to the accident because the road had fairly recent tarmac.

Specialist ambulance resources remained at the scene of the crash, near the Nerowie and Parwan-Exford roads intersection, into the evening.

Among them were two helicopter crews, two mobile intensive care ambulance paramedic crews and five advanced life support paramedic crews.

“Their priority is with their patients,” an Ambulance Victoria spokesperson said in a statement.

-with AAP