The Prince of Wales has led tributes to former England international Rob Burrow, who has died at the age of 41 after a lengthy battle with motor neurone disease.

Burrow spent his entire rugby league career with Leeds Rhinos and helped them win eight Super League titles.

He retired in 2017 but two years later it was revealed Burrow had been diagnosed with MND.

Rob Burrow holds a Leeds flag aloft in 2017. He won eight Super League titles with the Rhinos. Photo: AAP

After he raised millions to help build a new care centre for MND patients alongside former team-mate Kevin Sinfield, his death was confirmed by his former club on Sunday night (British time).

“A legend of rugby league, Rob Burrow had a huge heart,” Prince William wrote on his official X account.

A statement from Leeds read: “It is with deep sadness that we announce the death of our beloved son, husband, father, brother and friend.

“Rob has always been a true inspiration throughout his life whether that was on the rugby league field or during his battle with MND.

“He never allowed others to define what he could achieve and believed in his own ability to do more.

“The outpouring of love and support that Rob and the whole Burrow family have received over the last 4½ years meant so much to Rob.”

Rugby Football League chairman Simon Johnson said the “devastating news” had united rugby league in sadness, along with “the many others who have been touched and inspired by the courageous response of Rob, his family and friends since his diagnosis in December 2019”.

-AAP