Rob Ford, the former mayor of Toronto who gained global notoriety for admitting to smoking crack cocaine while in office, has died from cancer, his office said in a statement.

The Toronto city councillor, 46, had been undergoing treatment for an aggressive form of cancer that had recurred despite surgery and several rounds of chemotherapy.

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During his tumultuous 2010 to 2014 tenure as mayor of Canada’s most populous city, Ford admitted to smoking crack cocaine, buying illegal drugs and driving after drinking alcohol.

He was diagnosed in September 2014 with pleomorphic liposarcoma, a rare and hard-to-treat cancer found in soft, fatty tissue of the body, after he was admitted to a hospital with abdominal pain.

The man who replaced Ford as mayor, John Tory, offered his condolences, calling Ford “a man who spoke his mind and who ran for office because of the deeply felt convictions that he had.”