A man repeatedly tasered and shot with bean bag rounds by police during an incident in Melbourne has died in hospital.

Officers had gone to a property at North Frankston on Thursday as part of an active investigation.

They said a 46-year-old man subsequently barricaded himself inside the house, with negotiations continuing for close to four hours.

Shortly before 8 pm police attempted to enter the property and found the man armed with knives and in an agitated state.

“The man was confrontational and as a result, he was tasered multiple times to no avail and subsequently flexible baton rounds were used,” police said in a statement on Saturday.

“The man was then provided with immediate medical care when he appeared to become unresponsive during his arrest.”

He was admitted to hospital but died on Saturday morning.

No one else was in the home at the time of the incident and there were no other injuries.

Homicide Squad detectives will prepare a report for the coroner, which is standard procedure following a death in custody.

The Professional Standards Command will oversee the investigation.

-AAP