Four people have died and a teenager is fighting for life after a car crash in Victoria’s west.

A car carrying five females was travelling along Wannon-Nigretta Falls Rd at Bochara about 9.30am on Saturday when the driver lost control, hitting a tree.

Four people died at the scene.

The fifth, a teenage girl, was flown to the Alfred Hospital with upper body injuries, an Ambulance Victoria spokesman said.

The teenager remained in a critical condition as of Saturday afternoon, a spokeswoman confirmed.

Police cordoned off the area to allow major collision investigation unit detectives to probe the crash.

Victoria Police urged anyone who witnessed it to contact them.

-AAP