A young married couple are dead and two teenagers have been arrested following a horrific collision involving a stolen 4WD in Melbourne’s outer east.

Police say the accident happened after the teenagers allegedly travelled at “horrendous speeds” and ran a red light before crashing into a Holden Commodore in Wantirna South sabout 1am on Saturday.

Acting Superintendent Stuart McGregor said the parents of one of the deceased visited the crash site on Saturday morning.

“I’ve seen some pretty terrible incidents, this is probably up there. I’ve been able to explain how the collision occurred, but I can’t tell her why.

“This behaviour is just abhorrent,” Superintendent McGregor said.

“Dealing with them and talking to them and seeing that state of shock, you never want to see that.”

Police inspect scene of double fatal in Melbourne’s outer east on Saturday. Photo: AAP

Superintendent McGregor told reporters the “abhorrent” events seemed to be “a bit of a game” for the teenagers.

“There’s nothing fun about this, this is not a game, this is real life, this is where people have died and this is where people will be going to jail,” he told reporters at the scene of the crash on Saturday.

“Everyone in the community just cannot understand how someone can think it’s right to travel at speed – horrendous speeds – through a red light and then when you know you’ve done so much damage to another car, to another person, to two people, to think of themselves and just flee.”

A 32-year-old female driver of the black Holden Commodore was taken to hospital where she later died while her 38-year-old male passenger died at the scene.

The couple from The Basin, near the Dandenong Ranges National Park and about 30 kilometres from Melbourne’s CBD, had only been married for 12 months.

Major Collision Investigation Unit detectives, with assistance from the Eastern Crime Unit and Knox Crime Investigation Unit detectives, arrested the man and teenage girl at a residence in the outer Melbourne suburb of Belgrave about 1.15pm on Saturday.

The 19-year-old Boronia man and 15-year-old Belgrave girl are currently receiving medical treatment and remain under police guard.

The allegedly stolen Lexus after the crash. Photo: AAP