Victoria police say the state will lose at least 40 people between now and New Year as the recent carnage on the roads continued on Monday.

In a horror 24 hours, six people have now been killed on the state’s roads, after a woman died in a single-vehicle crash at Reedy Creek about 1.30pm on Monday.

Two men who were also in the car were flown to Royal Melbourne Hospital in a stable condition and a woman in her 30s was flown to The Alfred Hospital in a stable condition.

The fatal crash happened soon after Victoria Police Assistant Commissioner Doug Fryer made a public plea for people to drive safely following a horror 24 hours on the state’s roads.

Police are also hunting for the driver who left a 13-year-old cyclist for dead in Melbourne on Sunday.

“What sort of person hits a young girl and then doesn’t render assistance?” Mr Fryer said, adding the driver faced serious charges when found.

The girl is fighting for life in hospital with head injuries and broken bones. a hit-and-run in Melbourne’s north.

Police said the teenager was hit while she was riding her bike at the corner of Bell and Sussex streets at Coburg just after 8pm on Sunday.

The driver of the car, believed to be a dark-coloured BMW, stopped briefly before leaving the scene.

“There is absolutely no doubt that the person … was fully aware that they had just hit a 13-year-old girl on a bike,” Mr Fryer said.

“There is no mother or father or grandparent who would ever want this to happen to their child, let alone be left on the side of the road just to die by a person who leaves the scene and doesn’t even bother to stop to help.”

Four people were killed on country roads on Sunday, while a 70-year-old Maffra woman died in hospital on Monday after one of the crashes at Newry.

“What I want is every Victorian to make a contract with themselves, make a contract to be here for Christmas,” Mr Fryer said.

“Statistics will say we’ll lose another 40 between now and New Year. That doesn’t have to be the case.”

The weekend carnage began early that morning when a 19-year-old man died in a ute rollover at Balmattum in Victoria’s northeast.

There were multiple passengers in the tray of the ute and police are waiting to interview another 19-year-old man injured in the crash.

“We know that these young men were at the local hotel for some hours,” Mr Fryer said.

“The crash happened at about two o’clock in the morning. We’re certainly looking at whether drugs or alcohol was involved.”

Mr Fryer said police and drug and booze buses would be out in force in the city and across Victoria for Tuesday’s Melbourne Cup holiday.

“We know the country roads are more dangerous than the metro roads. We ask everyone to drive to the conditions, not to the posted limit,” Assistant Commissioner Fryer said.

“We need everyone to look at the environment, whether it’s dusk or dawn, raining or not.”

-with ABC, AAP