Residents have been forced to evacuate after a horror crash on a major Brisbane motorway unleashed a huge fireball and sent toxic smoke billowing over surrounding suburbs.

The smash on the Logan Motorway occurred between a B-double truck carrying hazardous material and an Audi that was allegedly stolen half an hour before about 8.15pm on Tuesday.

It forced the closure of the motorway in both directions near Loganlea and Kingston, in Brisbane’s south.

The B-double truck was carrying hazardous material. Photo: Moreton City News

Queensland Police made an emergency declaration for an exclusion zone under the state’s Public Safety Preservation Act due to the billowing toxic smoke. The order remained in effect on Wednesday morning.

The area encompasses a stretch of the Logan Motorway from the Wembley Road off and on-ramps, Station Road, the Logan Motorway on-ramp and Kingston Road.

An exclusion zone in Loganlea and Kingston after the crash. Photo: QPS

Motorists and other people have been advised to avoid the area.

People living the exclusion zone were asked to remain indoors and close their windows as noxious smoke filled the air.

Toxic smoke blankets neighbouring suburbs. Photo: Facebook

The Queensland Ambulance Service said the truck driver was taken to Logan Hospital in a stable condition for observation.

Police have turned their attention to the driver and passenger from the stolen Audi. They reportedly fled the scene on foot.