She may be in jail, but hundreds of sightings of disgraced tech billionaire Elizabeth Holmes are being made across the United States.

Sparked by the runaway success of Nathan Fielder’s latest documentary You Can See Everything, Elizabeth Holmes look-alike contests are springing up around the country.

New York City hosted its second contest on Saturday (local time), with participants donning black garb and making wide-eyed faces reminiscent of the movie and its viral trailer.

Holmes was founder of the failed blood-testing startup Theranos and is serving a lengthy federal prison sentence for defrauding investors.

Thirty-four days before reporting to a federal prison for her 11-year sentence, Holmes and her partner Billy Evans invited filmmaker Fielder into their home.

The resulting three-hour documentary blends intimate portrait with surreal, theatrical re-enactments (featuring actress Amanda Seyfried), questioning truth, media manipulation, and performance.

Released early last month, You Can See Everything has raked in more than US$80 million ($A116 million) at the box office and is now the second-highest grossing non-music documentary ever in North America, beating 2005’s March of the Penguins (US$77 million) and behind only Michael Moore’s 2005 film Fahrenheit 9/11 (US$119 million).

At the latest New York lookalike contest, some contestants held up tiny vials of blood as part of their impression, in a nod to Holmes’ 2014 Forbes magazine photoshoot. One woman wore handcuffs.

Tiny vials of blood were integral to many looks. Photo: Forbes/Victor Chu

Holmes mania has also swept to the US West Coast as well, with dozens entering a lookalike contest in San Francisco on the weekend.

The San Francisco Chronicle reported several hundred people watched on at Lafayette Park, where contestants were judged based on a business pitch, a staring contest, and a dance off.

Miami is thought to be the first major city to host a Holmes lookalike contest, on October 21. Their popularity has only soared since.

An Echo Park vintage shop in Los Angeles hosted a Nathan Fielder and Elizabeth Holmes double lookalike contest on Sunday local time, with US$50 prizes and free Sriracha honey turkey jerky up for grabs.