An investigation is underway after bullets were fired at a suburban home in Sydney for the second night in a row.

About 2.14am Wednesday emergency services were called to Faulds Road, Guildford West, following reports of a “public place shooting”.

Officers attached to Cumberland Police Area Command attended and found several shots had been fired into a house.

No injuries were reported.

Police established a crime scene and commenced inquiries into the circumstances surrounding the incident.

A short time later there were reports of a car on fire on Birmingham Avenue, Villawood.

Fire and Rescue NSW crews extinguished the blaze; however, the vehicle was destroyed.

Police are investigating whether the shooting and car fire are linked.

The latest attack follows the death of a grandmother killed inside a family property during a drive-by shooting on Monday evening.

Three people got out of a dark-coloured sedan but it was not clear how many opened fire at the house in Ambarvale on Sydney’s southwest outskirts, police said.

Emergency services were called to a Dickens Road property about 11pm on Monday and treated the woman before she died at the scene.

The home was riddled with bullet holes.

The attack was targeted but it was unclear if the woman inside the house was the intended victim, police said.

A 21-year-old woman and a 34-year-old man inside the home were not injured.

The occupants of the house, who authorities believed had lived there for six to eight weeks, were known to police.

Police were unable to interview some distraught family members and said they would give them more time to process the death.

“It’s tragic … your mother and the grandmother to your children has been shot by cowards that stood out the front of the house,” Detective Superintendent Grant Healey said.

Police continue to search for the three people seen getting out of the car.

Nearby resident Louise Hoser said she heard gunshots soon after 10.30pm.

“Within 20 minutes I went to bed and my bedroom just lit up with the police lights … they didn’t have the sirens going, but there was a lot of police presence and ambulances up there,” she told AAP.

“I woke my house up to alert them that something was happening … it was very distressing to hear the family, and shocking to find out she was an elderly lady.”

Bullet holes could be seen near stairs leading to the front of the home and on the front wall of the house.

Evidence markers dotted the driveway at the home on Tuesday as local officers and the homicide squad began their probe.

Police said members of the public would be key to their investigation and asked witnesses to contact Crime Stoppers.

-with AAP