An out-of-control car is believed to have crashed into the beer garden of a popular Daylesford hotel, killing and injuring multiple people.

The vehicle reportedly crashed into the Royal Hotel beer garden, striking patrons at the ‘‘packed’’ pub about 6pm on Sunday night.

Victoria Police confirmed three people had died and a number of others had been injured.

Ambulance Victoria said four people have been flown to Melbourne for treatment, two were driven to Ballarat and another driven to Melbourne.

Police have asked the public to avoid Daylesford so emergency services can access the scene.

Tweet from @SaraJones_7

Police tweeted on Sunday evening that emergency services were at the scene of a serious crash in Vincent Street, Daylesford.

‘‘As emergency services need access to the scene we ask that members of the public avoid the area. Police are putting diversions in place,” the police tweeted.

Nine News reported that a number of air ambulances were on its way to ferry victims of the tragic accident in the centre of the regional tourism town, about 115 kilometres north-west of Melbourne.

The spa town of Daylesford has a population of less than 3000 people.

Anyone who witnessed the incident or has dashcam/CCTV footage is urged to contact Crime Stoppers.

Infrastructure Minister Catherine King, whose federal Ballarat electorate includes Daylesford, asked the community to follow advice from emergency services as crews carry out their work.

“My thoughts are with all those at the scene, their friends and families and the broader Daylesford community,” she said in a statement on X, formerly known as Twitter.

-with AAP