Police investigating the disappearance of mother-of-four Samantha Kelly have found a body at Shelbourne, south-west of Bendigo in Victoria.

Two men and a woman were being questioned by police over the suspected murder of Ms Kelly, from Kangaroo Flat.

Ms Kelly, 39, was last seen near the shopping centre precinct on High Street at Kangaroo Flat, on the outskirts of Bendigo, at 3:20pm on January 20, 2016.

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It took 15 days for her to be reported missing, during which time she missed the first birthday of her youngest child, which her family said was extremely out of character for her.

The arrests took place on Thursday night and the three people spent the night in custody in Bendigo.

Kangaroo Flat woman Samantha Kelly. Photo: ABC

Victoria Police said no charges have yet been laid against the trio.

The police investigation has centred around two locations, a house in Bendigo and a house in Kangaroo Flat, where Ms Kelly was living with her four children and three other adults.

Police have had the Kangaroo Flat home taped off for the last two days and been looking through the house.

Ms Kelly’s children had been in the care of friends when she was reported missing but they are now with family.

Earlier this week, Detective Senior Sergeant O’Connell said Ms Kelly had not accessed her bank accounts or used her phone since she went missing.

“She was a prolific Facebook user and she hasn’t used her Facebook account since January 21,” he said.

Police have talked about her disappearance this week and said they have concerns for her and believe she has met with foul play.