Twitter has suffered a loss in the first published results since its highly anticipated US stock market debut last year.

The social media company told shareholders it lost $US511 million ($573 million) in the last three months of last year.

That is despite a doubling of revenue from a year ago to a better-than-expected $US243 million ($273 Million).

Investors reacted very negatively to the results, with Twitter shares sliding more than 10 per cent in after-hours trade.

More to come.