Actor-director dream-team Leonardo DiCaprio and Martin Scorsese are getting together again for another silver screen epic based on a famous novel.

DiCaprio will suit up as the terrifying American murderer H.H. Holmes, depicted in Erik Larson’s novel The Devil in the White City: Murder, Magic and Madness at the Fair That Changed America, which the film will be based on.

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Holmes maintained looked a gentleman but was a monster. Photo: AAP

According to reports in Variety, Scorsese and DiCaprio will re-unite two years after The Wolf of Wall Street for the long-in-development project.

It’s reportedly been in the pipelines and through various directors for near-on 10 years.

H.H. Holmes murdered between 27 and 200 people, most of whom were single young females, in his reign of terror.

The film will be set against the backdrop of the 1893 World’s Fair in Chicago.

Holmes used a hotel he modified into a murder dungeon near the fair, to lure his victims to their death.

It included gas pipelines directed straight into rooms and vats of acid and other dangerous liquid.

All the while, Holmes is famous for maintaining the image of a regal late 19th century gentleman.

It is unknown whether the movie will tell the story of the novel’s partnering plot of World’s Fair architect Daniel H. Burnham.

It will be the sixth collaboration between the lauded actor and director, with other titles including Shutter Island, Gangs of New York and The Aviator.